A pet chameleon who has lived his entire life in the confines of a cozy glass terrarium discovers adventure beyond his wildest imagination. When we first meet Rango (voice of Johnny Depp), the sheltered pet chameleon is safe in his terrarium, and embarking on epic adventures through the power of imagination. Then, suddenly, his safe existence is irrevocably upended thanks to a bump in the road that sends him soaring out of a car window and right onto the searing-hot asphalt of a desert highway. On the advice of a wise armadillo who relays the story of the Spirit of the West, our conical-eyed hero sets out in search of a town called Dirt, narrowly escaping a hungry hawk and encountering a self-sufficient pioneer named Beans (voice of Isla Fisher) along the way.