The year is 2025, and a mysterious virus has broken out in Scotland--a lethal illness that seems to affect only men. When Dr. Amanda MacLean reports this phenomenon, she is dismissed as hysterical. By the time her warning is heeded, it is too late. The virus becomes a global pandemic--and a political one. The victims are all men. The world becomes alien--a women's world. What follows is the immersive account of the women who have been left to deal with the virus's consequences, told through first-person narratives. Dr. MacLean; Catherine, a social historian determined to document the human stories behind the "male plague;" intelligence analyst Dawn, tasked with helping the government forge a new society; and Elizabeth, one of many scientists desperately working to develop a vaccine. Through these women and others, we see the uncountable ways the absence of men has changed society, from the personal--the loss of husbands and sons--to the political--the changes in the workforce, fertility and the meaning of family.